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. 2015 Feb 9;2015:752481. doi: 10.1155/2015/752481

Figure 5.

Figure 5

Effects of pioglitazone on metabolic changes and pain behaviour in HFD/STZ rats. Effects of pioglitazone treatment (10 mgkg−1, p.o.) versus vehicle from day 21–49, on (a) plasma glucose, (b) plasma insulin, and (c) hindpaw mechanical withdrawal thresholds in the HFD/STZ rat. Data are mean ± SEM. Group sizes day 0–49; Lean/Veh: n = 11; HFD/Veh: n = 11; HFD/STZ + vehicle: n = 10, HFD/STZ + pioglitazone: n = 10. Group sizes day 49 onwards; Lean/Veh: n = 6; HFD/Veh: n = 6; HFD/STZ + vehicle: n = 5; HFD/STZ + pioglitazone: n = 5. Analysis was by a Kruskal-Wallis test with Dunn's post hoc test: * P < 0.05, ** P < 0.01, and *** P < 0.001 (compared to HFD/Veh).