Table 4.
Linear regression model showed dependence of WMA from tHcy levels, GA, Apgar scores at 1 and 5 minutes, 1298AC, and 677CT/1298AC MTHFR genotypes. IVH resulted in being dependent on GA and bradycardia by the same model.
| WMA | P values |
|---|---|
| tHcy | 0.014 * |
| GA | 0.000 * |
| Apgar 1 | 0.000 * |
| Apgar 5 | 0.000 * |
| Altered flussimetry | 0.999 |
| Preeclampsia | 0.999 |
| PROM | 0.096 |
| 677CT | 0.297 |
| 677TT | 0.065 |
| 1298AC | 0.000 * |
| 1298CC | 0.270 |
| 677CT/1298AC | 0.000 * |
| IVH | |
| tHcy | 0.862 |
| GA | 0.000 * |
| Preeclampsia | 0.314 |
| PROM | 0.138 |
| Altered flussimetry | 0.410 |
| Bradycardia | 0.000 * |
| 677CT | 0.726 |
| 677TT | 0.522 |
| 1298AC | 0.101 |
| 1298CC | 0.999 |
| 677CT/1298AC | 0.390 |
*Statistical significance. P < 0.05. tHcy: total homocysteine; MTHFR: methylenetetrahydrofolate reductase; WMA: white matter abnormalities; IVH: intraventricular hemorrhage; PROM: premature rupture of membranes; BW: birth weight; GA: gestational age; PFO: patent foramen ovale; CT and TT: heterozygous and homozygous MTHFR 677 genotypes; AC and CC: heterozygous and homozygous MTHFR 1298 genotypes.