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. Author manuscript; available in PMC: 2016 Feb 19.
Published in final edited form as: Mol Cell. 2015 Feb 19;57(4):595–606. doi: 10.1016/j.molcel.2015.01.022

Figure 6.

Figure 6

Different D-loops species during HR-mediated DSB and gap repair. D-loops are a collection of different recombination joint molecules with different DNA junction architecture (3’-end, length, gap invasion) and different HR proteins bound to the individual DNA intermediates. D-loops can form during DSB repair (left) or replication fork-associated gap repair (right) and include nascent D-loops (before extension by DNA polymerase: 3’-end not incorporated or ± branch migration), where proteins involved in strand invasion (e.g. Rad51, Rad51 paralogs, Rad54, RPA, Rad52?, others?) are likely still bound to at least parts of the D-loop (top) and extended D-loops (bottom), where instead or in addition to HR proteins replication proteins (PCNA, RFC, DNA polymerase, RPA) will be present in the D-loop.