Table 2. Summary of various comparative results.
| Genetic model | Overall or subgroup | Study number(n) | Participants (n) | OR (95% CI) | Z | P | I2 (%) | Phet | |
|---|---|---|---|---|---|---|---|---|---|
| IL-6 -174 C/G | |||||||||
| C vs G | All | 8 | 12,564 | 1.00 (0.93, 1.08) | 0.08 | 0.93 | 27 | 0.21 | |
| Age | All excluding pediatric | 7 | 12,144 | 1.02 (0.95, 1.11) | 0.59 | 0.56 | 0 | 0.81 | |
| Pneumonia type | All excluding HAP | 7 | 11,952 | 1.00 (0.93, 1.08) | 0.08 | 0.93 | 37 | 0.14 | |
| Ethnicity | Caucasians | 7 | 12,144 | 1.02 (0.95, 1.11) | 0.59 | 0.56 | 0 | 0.81 | |
| Quality score | ≥11 | 4 | 6660 | 1.00 (0.90, 1.11) | 0.00 | 1.0 | 56 | 0.08 | |
| <11 | 4 | 5904 | 1.01 (0.90, 1.12) | 0.12 | 0.91 | 0 | 0.44 | ||
| Sample size | ≥500 | 3 | 10088 | 1.02 (0.94, 1.11) | 0.46 | 0.64 | 16 | 0.30 | |
| <500 | 5 | 2476 | 0.93 (0.79, 1.11) | 0.77 | 0.44 | 38 | 0.17 | ||
| CC vs GG | All | 8 | 3547 | 1.00 (0.84, 1.18) | 0.02 | 0.98 | 40 | 0.12 | |
| Age | All excluding pediatric | 7 | 3452 | 1.05 (0.88, 1.24) | 0.54 | 0.59 | 0 | 0.73 | |
| Pneumonia type | All excluding HAP | 7 | 3378 | 0.98 (0.83, 1.17) | 0.21 | 0.84 | 47 | 0.10 | |
| Ethnicity | Caucasians | 7 | 3452 | 1.05 (0.88, 1.24) | 0.54 | 0.59 | 0 | 0.73 | |
| Quality score | ≥11 | 4 | 1821 | 1.01 (0.80, 1.21) | 0.08 | 0.93 | 62 | 0.05 | |
| <11 | 4 | 1686 | 0.98 (0.77, 1.26) | 0.13 | 0.90 | 2 | 0.36 | ||
| Sample size | ≥500 | 3 | 2886 | 1.01 (0.84, 1.22) | 0.13 | 0.89 | 0 | 0.41 | |
| <500 | 5 | 661 | 0.94 (0.65, 1.37) | 0.32 | 0.75 | 63 | 0.04 | ||
| CG vs GG | All | 8 | 4733 | 0.95 (0.84, 1.07) | 0.90 | 0.37 | 33 | 0.16 | |
| Age | All excluding pediatric | 7 | 4564 | 0.96 (0.85, 1.09) | 0.65 | 0.52 | 33 | 0.18 | |
| Pneumonia type | All excluding HAP | 7 | 4481 | 0.97 (0.86, 1.11) | 0.40 | 0.69 | 7 | 0.38 | |
| Ethnicity | Caucasians | 7 | 4564 | 0.96 (0.85, 1.09) | 0.65 | 0.52 | 33 | 0.18 | |
| Quality score | ≥11 | 4 | 2901 | 0.94 (0.81, 1.09) | 0.82 | 0.41 | 68 | 0.03 | |
| <11 | 4 | 1832 | 0.96 (0.77, 1.19) | 0.39 | 0.69 | 0 | 0.77 | ||
| Sample size | ≥500 | 3 | 3709 | 1.02 (0.89, 1.17) | 0.23 | 0.82 | 0 | 0.50 | |
| <500 | 5 | 1024 | 0.71 (0.54, 0.94) | 2.42 | 0.02 | 0 | 0.41 | ||
| CC + CG vs GG | All | 8 | 6282 | 0.96 (0.86, 1.08) | 0.60 | 0.55 | 26 | 0.22 | |
| Age | All excluding pediatric | 7 | 6072 | 0.99 (0.88, 1.11) | 0.23 | 0.82 | 0 | <0.43 | |
| Pneumonia type | All excluding HAP | 7 | 5976 | 0.98 (0.87, 1.11) | 0.28 | 0.78 | 23 | 0.25 | |
| Ethnicity | Caucasians | 7 | 6072 | 0.99 (0.88, 1.11) | 0.23 | 0.82 | 0 | 0.43 | |
| Quality score | ≥11 | 4 | 3330 | 0.96 (0.84, 1.11) | 0.50 | 0.62 | 61 | 0.05 | |
| <11 | 4 | 2952 | 0.97 (0.79, 1.19) | 0.33 | 0.74 | 0 | 0.60 | ||
| Sample size | ≥500 | 3 | 5044 | 1.02 (0.90, 1.16) | 0.29 | 0.77 | 0 | 0.37 | |
| <500 | 5 | 938 | 0.77 (0.77, 1.01) | 1.91 | 0.06 | 4 | 0.39 | ||
| CC vs CG + GG | All | 8 | 6282 | 1.05 (0.93, 1.19) | 0.79 | 0.43 | 47 | 0.08 | |
| Age | All excluding pediatric | 7 | 6072 | 1.08 (0.95, 1.23) | 1.37 | 0.22 | 8 | 0.37 | |
| Pneumonia type | All excluding HAP | 7 | 5976 | 1.03 (0.90, 1.17) | 0.44 | 0.66 | 41 | 0.13 | |
| Ethnicity | Caucasians | 7 | 6072 | 1.08 (0.95, 1.23) | 1.23 | 0.22 | 8 | 0.37 | |
| Quality score | ≥11 | 4 | 3330 | 1.08 (0.88, 1.34) | 0.75 | 0.45 | 69 | 0.02 | |
| <11 | 4 | 2952 | 1.03 (0.88, 1.21) | 0.42 | 0.67 | 0 | 0.49 | ||
| Sample size | ≥500 | 3 | 5044 | 1.03 (0.90, 1.18) | 0.45 | 0.65 | 0 | 0.56 | |
| <500 | 5 | 1238 | 1.17 (0.85, 1.62) | 0.96 | 0.34 | 69 | 0.02 | ||
| IL-10 -592 C/A | |||||||||
| C vs A | All | 3 | 1440 | 1.20 (0.95, 1.52) | 0.85 | 0.40 | 90 | 0.0001 | |
| All in HWE | 2 | 1218 | 0.95 (0.73, 1.24) | 0.35 | 0.72 | 0 | 0.67 | ||
| CC vs AA | All | 3 | 441 | 1.38 (0.79, 2.42) | 1.14 | 0.25 | 84 | 0.002 | |
| All in HWE | 2 | 370 | 0.59 (0.29, 1.17) | 0.51 | 0.13 | 0 | 0.76 | ||
| CA vs AA | All | 3 | 396 | 0.74 (0.46, 1.20) | 1.21 | 0.23 | 0 | 0.45 | |
| All in HWE | 2 | 311 | 0.73 (0.41, 1.31) | 1.06 | 0.29 | 37 | 0.21 | ||
| CC + CA vs AA | All | 3 | 720 | 1.02 (0.65, 1.60) | 0.10 | 0.92 | 60 | 0.08 | |
| All in HWE | 2 | 609 | 0.72 (0.41, 1.27) | 1.13 | 0.26 | 0 | 0.38 | ||
| CC vs CA + AA | All | 3 | 720 | 1.38 (1.00, 1.91) | 0.62 | 0.54 | 78 | 0.01 | |
| All in HWE | 2 | 609 | 1.05 (0.74, 1.49) | 0.27 | 0.79 | 13 | 0.28 | ||
| IL-10 -1082 G/A | |||||||||
| A vs G | All | 3 | 1486 | 1.43 (0.72, 2.70) | 1.11 | 0.27 | 84 | 0.002 | |
| All in HWE | 2 | 1264 | 1.04 (0.83, 1.30) | 0.33 | 0.74 | 0 | 0.81 | ||
| AA vs GG | All | 3 | 384 | 1.35 (0.89, 2.03) | 1.42 | 0.16 | 77 | 0.01 | |
| All in HWE | 2 | 327 | 1.09 (0.70, 1.69) | 0.39 | 0.70 | 0 | 0.87 | ||
| AG vs GG | All | 3 | 532 | 1.38 (1.00, 1.91) | 1.07 | 0.28 | 0 | 0.51 | |
| All in HWE | 2 | 462 | 0.81 (0.54, 1.20) | 1.06 | 0.29 | 25 | 0.25 | ||
| AA + AG vs GG | All | 3 | 743 | 0.97 (0.69, 1.37) | 0.16 | 0.87 | 19 | 0.29 | |
| All in HWE | 2 | 632 | 0.89 (0.62, 1.29) | 0.62 | 0.54 | 0 | 0.49 | ||
| AA vs AG + GG | All | 3 | 743 | 1.65 (1.19, 2.28) | 1.29 | 0.20 | 87 | 0.0005 | |
| All in HWE | 2 | 632 | 1.21 (0.79, 1.83) | 0.87 | 0.38 | 17 | 0.27 |