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. Author manuscript; available in PMC: 2015 Jun 16.
Published in final edited form as: Nat Commun. 2014 Dec 16;5:5667. doi: 10.1038/ncomms6667

Figure 1. Transcriptome analysis of inside and outside cells at the 16-cell stage.

Figure 1

(a) Schematic representation of pre-implantation development. Briefly, two waves of asymmetric divisions at the 8-16 and 16-32 cell transitions set apart the outside progenitors of the TE (blue) and the inside progenitors of the ICM (pale yellow). Cells of the ICM will further segregate into the EPI and PE in the late blastocyst. (b) Isolation and deep sequencing of outside and inside cells from the 16-cell embryo. (c) BMP ligands and receptors differentially expressed at the 16-cell stage. (d) pSmad1 expression in the early blastocyst. Scale bars = 40 μm.