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. Author manuscript; available in PMC: 2015 Jun 16.
Published in final edited form as: Nat Commun. 2014 Dec 16;5:5667. doi: 10.1038/ncomms6667

Figure 2. Expression of dominant negative forms of Smad4 and Bmpr2 affects TE and PE development.

Figure 2

(a) One blastomere of two-cell embryos was injected with dnSmad4 (n = 21), dnBmpr2 (n = 22) or Gap43-RFP only (controls n = 20) and cultured to E4.5. (b) Total cell numbers for each lineage in the injected (Gap43-RFP-positive) half of the embryo. (c) Total cell numbers and lineage contributions relative to control. (d) Contribution of injected ICM cells to PE. * denotes p < 0.05, ** denotes p < 0.01, *** denotes p < 0.001 (Student’s t-test). Error bars represent s.e.m.