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. Author manuscript; available in PMC: 2015 Jun 16.
Published in final edited form as: Nat Commun. 2014 Dec 16;5:5667. doi: 10.1038/ncomms6667

Figure 7. Roles of BMP signalling in pre-implantation development.

Figure 7

BMP signalling is important for the development of both extra-embryonic cell lineages, the TE and PE. Inhibitors of both the Smad-dependent (Dorsomorphin) and Smad-independent ((5Z)-7-Oxozeaenol) BMP pathways impair development of the TE but have different effects on the PE. Blocking the Smad-dependent pathway results in the elimination of PE precursor cells, while blocking the Smad-independent pathway compromises the differentiation of PE cells.