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. Author manuscript; available in PMC: 2015 Jun 4.
Published in final edited form as: Nat Commun. 2014 Dec 4;5:5690. doi: 10.1038/ncomms6690

Figure 3. Somatic mutations in EGFR occur after focal amplifications in GBM.

Figure 3

a. Models of extrachromosomal mutations (in Double Minutes) (upper panel) and chromosomal mutation followed by amplification (lower panel). b. Allelic percentages of heterozygous germline variants and somatic mutations in EGFR focal amplifications. Heterozygous germline variants of allele A and B (blue and black circles); Somatic mutations (red stars). GBM tumors were reanalyzed from TCGA consortium.