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. Author manuscript; available in PMC: 2015 Jun 4.
Published in final edited form as: Nat Commun. 2014 Dec 4;5:5690. doi: 10.1038/ncomms6690

Figure 6. Model of generation and function of Amplification-Linked Extrachromosomal Mutations (ALEMs).

Figure 6

After random generation of the DM molecules, the amplified DNA region is prone to acquisition of an ALEM due to a higher number of DNA copies. The cell with the highest number of DMs harboring the ALEM will have a proliferative advantage. In response to environmental stress the cells may accordingly change the amount of DMs (see text for details).