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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Nature. 2014 Dec 15;517(7532):50–55. doi: 10.1038/nature14063

Extended Data Figure 7. Alignment of the channel domain sequences of RyR orthologues.

Extended Data Figure 7

Secondary structural elements are indicated above the sequence alignment. Invariant amino acids are shaded in grey. The residues that may constitute potential cation binding sites are cored red. The C2H2 zinc finger motif is highlighted with green background. The residues whose mutations or deletions have been identified in patients are indicated with colored circles below the sequences. The color code is annotated at the bottom. CCD: central core disease; CRD: core/rod disease; MHS: malignant hyperthermia susceptibility; CPVT1: catecholaminergic polymorphic ventricular tachycardia type 1.