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. 2015 Jan 12;6:5999. doi: 10.1038/ncomms6999

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(a) Raw data showing persistent K⁺ currents in control, TARDBP and C9ORF72 iPSC-derived MNs at week 3–4 and weeks 9–10. (b) Current–voltage relationships of peak K⁺ currents recorded from control and patient iPSC-derived MNs at weeks 3–4. (c) Current–voltage relationships of peak K⁺ currents recorded from control and patient iPSC-derived MNs at weeks 9–10. (d) Peak K⁺ currents plotted from weeks 3–10 for control (n=847), TARDBP (n=452) and C9ORF72 (n=264) iPSC-derived MNs (data are plotted as ; *significantly different to control, P<0.05; ***significantly different to control, P<0.0001; #significant difference between patient lines, P<0.05; ###significant difference between patient lines, P<0.0001; linear model with multiple Wald’s tests and Bonferroni correction).

Inline graphic — (a) Raw data showing persistent K⁺ currents in control, TARDBP and C9ORF72 iPSC-derived MNs at week 3–4 and weeks 9–10. (b) Current–voltage relationships of peak K⁺ currents recorded from control and patient iPSC-derived MNs at weeks 3–4. (c) Current–voltage relationships of peak K⁺ currents recorded from control and patient iPSC-derived MNs at weeks 9–10. (d) Peak K⁺ currents plotted from weeks 3–10 for control (n=847), TARDBP (n=452) and C9ORF72 (n=264) iPSC-derived MNs (data are plotted as ; *significantly different to control, P<0.05; ***significantly different to control, P<0.0001; #significant difference between patient lines, P<0.05; ###significant difference between patient lines, P<0.0001; linear model with multiple Wald’s tests and Bonferroni correction).