Table 1.
Patient demographics and baseline characteristics (FAS)
| PLA-DON10 | DON5-DON10 | DON10-DON10 | DON-DON10 | |
|---|---|---|---|---|
| ( n = 37) | ( n = 45) | ( n = 49) | ( n = 94) | |
| Sex, number (%) | ||||
| Male | 14 (37.8) | 20 (44.4) | 21 (42.9) | 41 (43.6) |
| Female | 23 (62.2) | 25 (55.6) | 28 (57.1) | 53 (56.4) |
| Age, years | 76.7 ± 6.0 | 78.8 ± 5.1 | 77.7 ± 6.8 | 78.2 ± 6.1 |
| Weight, kg | 51.52 ± 10.68 | 50.68 ± 9.24 | 51.72 ± 9.89 | 51.22 ± 9.55 |
| Duration of dementia, years | 2.1 ± 2.4 | 2.7 ± 1.8 | 2.3 ± 1.9 | 2.5 ± 1.9 |
| History of antidementia medication, number (%) | ||||
| Yes | 1 (2.7) | 3 (6.7) | 4 (8.2) | 7 (7.4) |
| No | 36 (97.3) | 42 (93.3) | 45 (91.8) | 87 (92.6) |
| Visual hallucinations, number (%) | ||||
| Yes | 37 (100.0) | 39 (86.7) | 39 (79.6) | 78 (83.0) |
| No | 0 | 6 (13.3) | 10 (20.4) | 16 (17.0) |
| Cognitive fluctuation, number (%) | ||||
| Yes | 34 (91.9) | 41 (91.1) | 46 (93.9) | 87 (92.6) |
| No | 3 (8.1) | 4 (8.9) | 3 (6.1) | 7 (7.4) |
| Parkinsonism, number (%) | ||||
| Yes | 32 (86.5) | 39 (86.7) | 44 (89.8) | 83 (88.3) |
| No | 5 (13.5) | 6 (13.3) | 5 (10.2) | 11 (11.7) |
| Hoehn & Yahr, number (%) | ||||
| I | 4 (10.8) | 8 (17.8) | 7 (14.3) | 15 (16.0) |
| II | 15 (40.5) | 17 (37.8) | 19 (38.8) | 36 (38.3) |
| III | 13 (35.1) | 14 (31.1) | 18 (36.7) | 32 (34.0) |
| MMSE | 20.2 ± 4.3 | 20.6 ± 4.1 | 20.3 ± 4.8 | 20.4 ± 4.4 |
| NPI-2 | 6.9 ± 3.9 | 6.9 ± 4.5 | 7.3 ± 4.7 | 7.1 ± 4.6 |
| NPI-10 | 19.1 ± 13.5 | 18.9 ± 15.3 | 16.6 ± 11.7 | 17.7 ± 13.5 |
| ZBI | 26.0 ± 15.4 | 28.3 ± 18.5 | 31.4 ± 17.8 | 29.9 ± 18.1 |
FAS, full analysis set, MMSE, Mini-Mental State Examination, NPI: Neuropsychiatric Inventory, ZBI: Zarit Caregiver Burden Interview. Values are expressed as mean ± SD, unless otherwise specified.