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. Author manuscript; available in PMC: 2015 Aug 12.
Published in final edited form as: Nature. 2015 Jan 14;518(7538):236–239. doi: 10.1038/nature14142

Extended Data Figure 10. RNAi of RBM3 down-regulation accelerates impaired structural synaptic plasticity in the 5×FAD mouse model, and also reduced synapse number and function in wild type mice.

Extended Data Figure 10

Impaired structural synaptic plasticity after cooling occurs in shRNA-RBM3 treated 5×FAD mice at 3 months. Representative electron micrographs are shown and are pseudo-coloured as in main text figures. Quantification shows significant reduction in synapse number by RNAi of RBM3. (n = 82-93 images from 3 mice per time point, Student’s t-test, two tailed) b) RBM3 knockdown reduces synapse number and novel object memory in wild type mice. (n =93 images from 3 mice per time point, Student’s t-test, two tailed ***p <0.0001; n.o.r. n=11 mice LV-shRNA-control and 10 mice LV-shRNA-RBM3, Mann Whitney U test, * p <0.05). Scale bar = 1μm