Figure 2. The FN-induced phospho-adhesome.

(a) Adhesome components6 identified from the combined proteomic and phosphoproteomic analysis of isolated adhesion complexes were mapped onto a human PPI network and organized according to functional category. Grey nodes represent proteins identified by the proteomic analysis but not the phosphoproteomic analysis (no phosphorylation). All other nodes represent proteins identified by the phosphoproteomic analysis and are displayed as pie charts showing the relative levels of phosphorylated serine, threonine and tyrosine residues on each protein. These nodes are also displayed in different sizes to reflect the total number of phosphorylated residues identified from each protein. (b) All phosphorylated GEFs and GAPs identified from isolated adhesion complexes are displayed. Nodes surrounded by a grey box represent adhesome components.