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. Author manuscript; available in PMC: 2015 Aug 15.
Published in final edited form as: J Immunol. 2015 Jan 14;194(4):1983–1995. doi: 10.4049/jimmunol.1402481

Figure 1. Genetic deletion of TLR2, but not MD-2, in mice results in severe chemotherapy-induced intestinal mucositis.

Figure 1

Mice (WT, MD-2 KO, TLR2 KO, TLR2/MD-2 dKO) were treated with or without i.p. MTX [40 mg/kg BW] once daily for 4 days and sacrificed on day 7, as described in Materials and Methods. (A) Representative cross sections of proximal jejunum (H&E staining; scale bar, 100 μm). (B) Histological mucositis scores of proximal jejunum, terminal ileum and distal colon (n = 4-5/group). (C) Body weight change in relation to day 0 (n = 3-6/group). (D) MPO activity (n = 3-5/group). Data are presented as means ± SEM (*p < 0.05, **p < 0.01, ***p < 0.001). Pooled or representative data from at least two independent experiments are shown.