Table 2. Ten years estimated hazard ratios (HR) for death in patients with ovarian cancer.
| Conventional Cox model | Cox model with time-varying-effect | |||||
|---|---|---|---|---|---|---|
|
|
||||||
| Variable (Reference) | HR | 95% CI | p-value | HR | 95% CI | p-value |
| Age (per year) | 1.02 | 1.02-1.02 | <0.001 | 1.02 | 1.02-1.02 | <0.001 |
| Grade (ref: low) | 1.66 | 1.40-1.96 | <0.001 | 1.64 | 1.38-1.94 | <0.001 |
| Regional (ref: localized) | 2.89 | 2.41-3.47 | <0.001 | 2.87 | 2.40-2.44 | <0.001 |
| Distant (ref: localized) | 6.64 | 5.58-7.90 | <0.001 | 6.59 | 5.54-7.84 | <0.001 |
| Serous (ref: non-serous) | 1.08 | 0.99-1.17 | 0.10 | 1.07 | 0.98-1.17 | 0.13 |
| BRCA1 (ref: non carriers) | 0.83 | 0.74-0.93 | 0.002 | 0.53 | 0.43-0.66 | <0.001 |
| BRCA2 (ref: non carriers) | 0.55 | 0.47-0.65 | <0.001 | 0.42 | 0.30-0.59 | <0.001 |
| BRCA1*_t | 1.14 | 1.08-1.20 | <0.001 | |||
| BRCA2*_t | 1.09 | 1.01-1.18 | 0.048 | |||
*
_t: time-varying Hazard Ratio