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Kras; p16p19null mouse myogenic tumors metastasize to the lungs of tumor-bearing animals. Random lung sections from Kras; p16p19null tumor-bearing mice show metastases. Tumor cells invade lung capillaries (top panel). Similar to primary tumors arising from GFP+ Kras-expressing; p16p19null satellite cells, lung metastases are GFP+ (bottom right panel). Images were taken at 10× and 20× (scale bars indicate 100 μm)
