Figure 1.

Carotid plaques from DKO mice are less stenotic. A, Study timeline. B, Plaque length and percent stenosis (C) calculated from UBM measurements. The rate of plaque development was calculated by linear regression of data points for each individual animal over time n=11 (DKO) and 14 (Apoe−/−). C, The slopes of the percent stenosis change with time were compared and significance determined by independent sample t test. *P<0.05. D, Plaque length measured from postmortem whole mounts and percent stenosis calculated from histological sections of 9 weeks postsurgery tissue. Each symbol represents 1 plaque. Data analyzed by independent sample t test. n=18 (DKO) to 19 (Apoe−/−). **P<0.01. Apo indicates apolipoprotein; DKO, double knockout; UBM, ultrasound biomicroscopy.