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Plaques in double knockout (DKO) mice are more stable. A, Representative trichrome‐stained plaques. †Necrotic regions. B, Plaque scoring scale (left) and data (right). Group ranks were significantly different by Mann–Whitney's nonparametric test; **P<0.01. C, Quantitation of necrotic area. Data (mean±SEM) analyzed by independent sample t test; *P<0.05. B and C, Each symbol represents 1 animal. n=18 (DKO) or 19 (Apoe−/−). Apo indicates apolipoprotein.
