Figure 4.

Double knockout (DKO) plaques have less lipid. A, Representative Oil Red O (ORO)‐stained plaques showing lipid distribution. Quantitation of overall ORO‐positive area and the size of individual lipid‐positive foci; n=10 (Apoe^−/−) to 11 (DKO). B, Relative mRNA expression of scavenger receptors in carotid plaques; n=5 (DKO) to 6 (Apoe^−/−). Data (mean±SEM) analyzed by independent sample t test, *P<0.05; **P<0.01. Apo indicates apolipoprotein; LOX‐1, lectin‐like oxidized low‐density lipoprotein receptor 1; SR‐A, scavenger receptor class A.