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. 2014 Dec 16;3(6):e001232. doi: 10.1161/JAHA.114.001232

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© 2014 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Figure 9. — Immune complexes induce M2 polarization in DKO MØ. Peritoneal macrophages were not treated (NT) or stimulated with immune complexes (IC) or LPS+IC (6 hours). RNA was isolated and quantified by qRT‐PCR. B, Protein levels of IL‐10 and IL‐12 from the media of samples in (A). Apoe^−/− white bars, DKO black bars (n=3). Significance was determined by independent sample t test. n.d., not detected. *P<0.05; ***P<0.001. Apo indicates apolipoprotein; Arg‐1, arginase 1; DKO, double knockout; IL, interleukin; iNOS, inducible nitric oxide synthase; LPS, lipopolysaccharide; qRT‐PCR, quantitative real‐time polymerase chain reaction; TNF‐α, tumor necrosis factor alpha.