Table 4.
Baseline Characteristics of the Study Population With Different MmiR‐126 Level*
| Characteristic | Total (n=176) | Low MmiR‐126 (n=88) | High MmiR‐126 (n=88) | P Value |
|---|---|---|---|---|
| Age, y | 66.7±10.2 | 66.2±10.7 | 67.2±9.7 | 0.487 |
| Sex, no. (%) | 0.25 | |||
| Female | 53 (30.1) | 30 (34.1) | 23 (26.1) | |
| Male | 123 (69.9) | 58 (65.9) | 65 (73.9) | |
| Cardiovascular risk factors, no. (%) | ||||
| Arterial hypertension | 148 (84.1) | 76 (86.4) | 72 (81.8) | 0.410 |
| Hyperlipoproteinemia | 145 (82.4) | 74 (84.1) | 71 (80.7) | 0.553 |
| Diabetes | 50 (28.4) | 30 (34.1) | 20 (22.7) | 0.095 |
| Family history of CAD | 26 (14.8) | 12 (13.6) | 14 (15.9) | 0.671 |
| Smoking | 34 (19.3) | 15 (17) | 19 (21.6) | 0.445 |
| Body mass index, kg/m2 | 28.1±4.8 | 28.5±4.8 | 27.7±4.9 | 0.266 |
| Laboratory parameters | ||||
| Cholesterol, mg/dL | 192.3±44 | 195.9±48 | 188.8±39 | 0.364 |
| LDL cholesterol, mg/dL | 115.6±36.4 | 111.7±36.7 | 119.3±36.1 | 0.274 |
| HDL cholesterol, mg/dL | 50.7±13.6 | 49.2±11.8 | 52.1±15 | 0.260 |
| Triglycerides, mg/dL | 156.4±111 | 174.7±137 | 138.4±74.7 | 0.065 |
| Serum creatinine, mg/dL | 1.1±1.1 | 1.1±0.9 | 1.2±1.3 | 0.651 |
| Glomerular filtration rate, mL/min | 77.0±23.9 | 76±22.4 | 77.9±25.4 | 0.614 |
| Leucocytes, 109/L | 7.03±1.86 | 7.15±1.96 | 6.91±1.76 | 0.430 |
| C‐reactive protein, mg/L | 9.5±14.7 | 8.6±10.9 | 10.4±18 | 0.510 |
| Medical history, no. (%) | ||||
| Previous MI (6 months) | 54 (30.7) | 26 (29.5) | 28 (31.8) | 0.744 |
| Previous PCI | 76 (43.2) | 39 (44.3) | 37 (42.4) | 0.761 |
| Left ventricular ejection fraction, % | 58.9±15.8 | 57.5±16.4 | 60.2±15.1 | 0.276 |
| Medication on admission, no. (%) | ||||
| ACE inhibitors | 102 (58) | 51 (58) | 51 (58) | 1 |
| Angiotensin receptor blockers | 18 (10.2) | 10 (11.4) | 8 (9.1) | 0.619 |
| Beta blockers | 115 (65.3) | 58 (65.9) | 57 (64.8) | 0.874 |
| Calcium channel blockers | 30 (17) | 19 (21.6) | 11 (12.5) | 0.109 |
| Diuretics | 69 (39.2) | 35 (39.8) | 34 (38.6) | 0.877 |
| Statins | 98 (55.7) | 53 (60.2) | 45 (51.1) | 0.225 |
| Nitrates | 57 (32.4) | 30 (34.1) | 27 (30.7) | 0.629 |
| Aspirin | 122 (69.3) | 62 (70.5) | 60 (68.2) | 0.744 |
| Clopidogrel | 33 (18.8) | 13 (14.8) | 20 (22.7) | 0.176 |
| Annexin V/CD31+ MV (log10 value) | 3.34±0.5 | 3.38±0.5 | 3.30±0.5 | 0.311 |
Chronic kidney disease was defined as a glomerular filtration rate <60 mL/min. ACE indicates angiotensin‐converting enzyme; CAD, coronary artery disease; HDL, high‐density lipoprotein; LDL, low‐density lipoprotein; MI, myocardial infarction; MmiR, microRNA in circulating microvesicles; MV, microvesicles; PCI, percutaneous coronary intervention.
*
According to the median of MmiR‐126.