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. 2014 Nov 11;3(6):e001263. doi: 10.1161/JAHA.114.001263

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© 2014 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Figure 2. — iPSC generation from control and patients with HCM. A, Immunostaining for human pluripotent stem cell markers, Nanog, OCT 3/4, SSEA 3, SSEA 4, TRA‐1‐60, and TRA‐1‐81. B, Teratoma formation from control 1 , HCM 1 , HCM 2, and HCM3 iPSCs in the immunocompromised NOD‐SCID mice. Sections of teratomas were stained with hematoxylin–eosin, and tissues representative of all 3 germ layers were observed. HCM indicates hypertrophic cardiomyopathy; iPSCs, induced pluripotent stem cells.