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. 2014 Nov 11;3(6):e001263. doi: 10.1161/JAHA.114.001263

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© 2014 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Figure 6. — Structural characterization of iPSC‐derived cardiomyocytes. A, Electron microscopic images showing well‐organized striated myofibrils derived from beating EBs from control and HCM iPSCs at 60 days after differentiation. Scale bars, 1 μm. B, Electron microscopic images showing myofibrillar disarray derived from beating EBs from HCM iPSC at 60 days after differentiation. Scale bars, 1 μm. C, Immunostaining for cTnT in the single cardiomyocytes at 60 days derived from each HCM iPSC, showing myofibrillar disarray. D, The percentages of cardiomyocytes with myofibrillar disarray were assessed by cTnT immunostaining of the single cardiomyocytes. N=851 to 995. *P<0.05, **P<0.01 vs control in the same time point (χ² test). cTnT indicates cardiac troponin T; EBs, embryoid bodies; HCM, hypertrophic cardiomyopathy; iPSC, induced pluripotent stem cell.