Figure 11.

ET‐1 augments myofibrillar disarray in HCM iPSC‐derived cardiomyocytes. A, Electron microscopic observation of beating EBs at 60 days, which were cultured with ET‐1, Ang II, IGF‐1, or PE for 7 days. Scale bars, 1 μm. B and C, Relative gene expression of EDNRA and EDNRB in beating EBs at 30 days, normalized against TNNT2. N=3 (Control=3, HCM 1=3, HCM 1=3, HCM 3=3) (Kruskal–Wallis test). Ang II indicates angiotensin II; EBs, embryoid bodies; EDNRA, endothelin receptor type A; ET‐1, endothelin‐1; HCM, hypertrophic cardiomyopathy; IGF‐1, insulin‐like growth factor‐1; iPSC, induced pluripotent stem cell; PE, phenylephrine.