Table 2.
Histopathologic and In Vitro Baseline Contractile Parameters in the Myectomy Specimens of the Study Population (N=122)
| Variable | |
|---|---|
| Histopathology | |
| Myocyte disarray | |
| None to minimal | 18 (15%) |
| Mild | 46 (38%) |
| Moderate | 42 (34%) |
| Severe | 16 (13%) |
| Interstitial fibrosis | |
| None to minimal | 16 (13%) |
| Mild | 61 (50%) |
| Moderate | 31 (25%) |
| Severe | 14 (12%) |
| SICAD | |
| None | 43 (37%) |
| Mild | 57 (47%) |
| Moderate | 20 (16%) |
| Severe | 2 (2%) |
| Baseline contractile parameters at 37°C and 1.0 Hz | |
| RT, g/mm2 | 2.8±1.1 (normal 2.7±1.1) |
| DT, g/mm2 | 1.4±0.8 (normal 1.6±0.8) |
| TPT, ms | 210±30 (normal 178±35) |
| THR, ms | 150±20 (normal 134±19) |
| +dT/dt, g/mm2 per second | 9.1±4.1 (normal 12.5±5) |
| −dT/dt, g/mm2 per second | 8.2±3.9 (normal 10.9±4) |
Normal values for contractile parameters (±SD) were derived from nonfailing normal hearts (obtained from healthy organ donors deemed unsuitable for transplantation but who had no history of cardiac disease). Values given as n (%) or mean±SD. Please see reference 14. SICAD, small intramural coronary arteriole dysplasia; RT, resting tension; DT, developed tension; THR, time to half relaxation; TPT, time to peak tension; +dT/dt indicates maximum rate of tension rise; –dT/dt, maximum rate of tension fall.