Table 2.
Risk of AF With PAD
| Subgroup | Events/No. at Risk | Model 1* HR (95% CI) | P Value | Model 2* HR (95% CI) | P Value | Interaction P Value* |
|---|---|---|---|---|---|---|
| All | 301/6568 | 1.7 (1.3 to 2.2) | 0.0004 | 1.5 (1.1 to 2.0) | 0.0041 | — |
| Age, years* | ||||||
| <62 | 43/3218 | 2.2 (0.93 to 5.4) | 0.071 | 1.8 (0.74 to 4.4) | 0.20 | 0.79 |
| ≥62 | 258/3350 | 1.9 (1.4 to 2.5) | <0.0001 | 1.7 (1.3 to 2.3) | 0.0003 | |
| Sex | ||||||
| Female | 115/3454 | 1.7 (1.1 to 2.6) | 0.0098 | 1.6 (1.1 to 2.5) | 0.028 | 0.64 |
| Male | 186/3114 | 1.6 (1.1 to 2.4) | 0.012 | 1.5 (1.01 to 2.2) | 0.043 | |
| Race/ethnicity | ||||||
| White | 166/2519 | 1.6 (1.1 to 2.3) | 0.022 | 1.5 (0.98 to 2.2) | 0.064 | 0.71 |
| Nonwhite | 135/4049 | 1.8 (1.2 to 2.7) | 0.0038 | 1.6 (1.04 to 2.4) | 0.034 | |
AF indicates atrial fibrillation; CI, confidence interval; HR, hazard ratio; PAD, peripheral arterial disease.
*
Adjusted for Model 1 covariates plus smoking status, systolic blood pressure, diabetes, body mass index, total cholesterol, high‐density lipoprotein cholesterol, aspirin, antihypertensive and lipid‐lowering medications, high‐sensitivity C‐reactive protein levels, and left ventricular hypertrophy.
*
Interactions tested using Model 2.
*
Dichotomized at the median age for study participants.