Table 3.
Baseline Characteristics of HME (n=13) and Control Subjects (n=13)
| HME Carriers | Controls | P Value | |
|---|---|---|---|
| Age, y | 40±10 | 41±10 | |
| Male/female, N | 4/9 | 4/9 | |
| BMI, kg/m2 | 23.8±2.9 | 23.9±2.5 | NS |
| Smoking, N | 1 | 1 | |
| Family history CVD | 2 | 4 | |
| Family history diabetes | 3 | 3 | |
| Cholesterol (C), mmol/L | 4.8±0.5 | 4.5±0.6 | 0.58 |
| LDL‐C, mmol/L | 2.5±0.8 | 2.3±0.4 | 0.76 |
| HDL‐C, mmol/L | 1.5±0.3 | 1.4±0.3 | 0.53 |
| Triglycerides, mmol/L | 0.9 [0.7 to 1.4] | 0.8 [0.7 to 1.0] | 0.30 |
| Fasting glucose, mmol/L | 4.8±0.5 | 4.9±0.6 | 0.63 |
| Creatinine, μmol/L | 71±11 | 67±12 | 0.41 |
| Calculated eGFR, mL/min per 1.73 | >60 | >60 | |
| CRP, g/L | 1.7±1.7 | 1.2±0.6 | 0.34 |
| 24‐h urinary albumin excretion, mg/L | 4.8±3.5 | 4.8±2.5 | 0.98 |
| SBP, mm Hg | 127±11 | 132±14 | 0.40 |
| DBP, mm Hg | 80±8 | 78±10 | 0.70 |
| Mutation in EXT1/EXT2 | 9/4 |
Data are presented as mean±SD except for triglycerides, which are presented as median and interquartile range. Data were analyzed using Student t test statistics. BMI indicates body mass index; CRP, C‐reactive protein; CVD, cardiovascular disease; DBP, diastolic blood pressure; e‐GFR, estimated glomerular filtration rate; EXT, exostosin; HDL‐C, high‐density lipoprotein cholesterol; HME, hereditary multiple exostosis; LDL‐C, low‐density lipoprotein cholesterol; NS, not significant; SBP, systolic blood pressure.