Table 2.
Associations of Parathyroid Hormone (PTH) and 25‐Hydroxyvitamin D (25[OH]D) With Incident Heart Failure in the Multi‐Ethnic Study of Atherosclerosis (N=6459)
| Covariate | Number at Risk | Number of Events | Unadjusted Incidence Rate (per 1000 pys) | HR (95% CI) | ||
|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | ||||
| PTH | ||||||
| <65 pg/mL | 5684 | 138 | 3.1 | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) |
| ≥65 pg/mL | 775 | 42 | 7.4 | 1.96 (1.39, 2.77) | 1.44 (1.00, 2.06) | 1.50 (1.03, 2.19) |
| 25(OH)D | ||||||
| ≥30 ng/mL | 2110 | 53 | 3.2 | Ref | Ref | Ref |
| 20 to 29 ng/mL | 2112 | 62 | 3.8 | 1.19 (0.82, 1.72) | 1.02 (0.69, 1.51) | 0.95 (0.64, 1.41) |
| <20 ng/mL | 2237 | 65 | 3.9 | 1.29 (0.84, 1.98) | 1.04 (0.66, 1.63) | 0.97 (0.61, 1.55) |
Model 1: adjusted for age, sex, race/ethnicity, education. Model 2: Model 1+height, weight, smoking, physical activity level, diabetes, eGFR, urine ACR, systolic blood pressure, antihypertensive medications. Model 3: Model 2+ calcium, phosphorus, FGF‐23, PTH/25(OH)D (alternative measure to the predictor). ACR indicates albumin to creatinine ratio; eGFR, estimated glomerular filtration rate; HR, hazard ratio; pys, person years.