Table 4.

Associations of Parathyroid Hormone (PTH) and 25‐Hydroxyvitamin D (25[OH]D) With Incident Heart Failure in the Multi‐Ethnic Study of Atherosclerosis, Adjusted for Baseline Left Ventricular Mass (LVM) (N=4759)^**

Covariate	Number at Risk	Number of Events	Unadjusted Incidence Rate (per 1000 pys)	HR (95% CI)
				Model 3a	Model 3b
PTH
<65 pg/mL	4240	89	2.7	Ref	Ref
≥65 pg/mL	519	25	6.6	1.67 (1.01, 2.75)	1.34 (0.78, 2.3)
25(OH)D
≥30 ng/mL	1631	34	2.6	Ref	Ref
20 to 29 ng/mL	1661	42	3.3	1.08 (0.66, 1.77)	1.17 (0.71, 1.91)
<20 ng/mL	1467	38	3.5	1.17 (0.65, 2.10)	1.19 (0.64, 2.20)

Model 3a: adjusted for age, sex, race/ethnicity education, height, weight, smoking, physical activity level, diabetes, eGFR, urine ACR, systolic blood pressure, antihypertensive medications, calcium, phosphorus, FGF‐23, PTH/25(OH)D (alternative measure to the predictor). Model 3b: Model 1+baseline LVM. ACR indicates albumin to creatinine ratio; eGFR, estimated glomerular filtration rate; pys, person years.

^*These analyses were based on a complete case approach in which participants with missing covariate data were excluded (rather than using multiple imputation for missing covariates as was done for the primary analyses).

^*This analysis excluded 4 participants who did not have time‐to‐event data available.