Table 5.

Associations of Parathyroid Hormone (PTH) With Incident Preserved and Reduced Ejection Fraction (EF) Heart Failure in the Multi‐Ethnic Study of Atherosclerosis (N=6458)^**

	Number at Risk	Number of Events	Unadjusted Incidence Rate (per 1000 pys)	Model 1	HR (95% CI)
					Model 2	Model 3
Preserved EF
PTH <65 pg/mL	5683	47	1.1	Ref	Ref	Ref
PTH ≥65 pg/mL	775	12	2.1	1.84 (1.00, 3.39)	1.43 (0.76, 2.71)	1.41 (0.74, 2.69)
Reduced EF
PTH <65 pg/mL	5683	59	1.3	Ref	Ref	Ref
PTH ≥65 pg/mL	775	24	4.2	2.66 (1.65, 4.29)	1.92 (1.14, 3.25)	1.90 (1.10, 3.30)

Model 1: adjusted for age, sex, race/ethnicity, education. Model 2: Model 1+height, weight, smoking, physical activity level, diabetes, eGFR, urine ACR, systolic blood pressure, antihypertensive medications. Model 3: Model 2+calcium, phosphorus, FGF‐23, 25(OH)D. ACR indicates albumin to creatinine ratio; eGFR, estimated glomerular filtration rate; HR, hazard ratio; LVEF, left ventricular ejection fraction; pys, person years.

^*These analyses were based on a complete case approach in which participants with missing covariate data were excluded (rather than using multiple imputation for missing covariates as was done for the primary analyses).

^*One participant did not have LVEF information at the time of hospitalization and so was excluded from this analysis.