Table 6.
Associations of Parathyroid Hormone (PTH) and 25‐Hydroxyvitamin D (25[OH]D) With Incident Heart Failure in the Multi‐Ethnic Study of Atherosclerosis (N=6347), Adjusted for Non‐Fatal MI*
| Covariate | Number at Risk | Number of Events | Unadjusted Incidence Rate (per 1000 pys) | HR (95% CI) | |
|---|---|---|---|---|---|
| Model 3a | Model 3b | ||||
| PTH | |||||
| <65 pg/mL | 5594 | 136 | 3.1 | 1.00 (Ref) | 1.00 (Ref) |
| ≥65 pg/mL | 753 | 39 | 7.0 | 1.46 (0.99, 2.14) | 1.42 (0.95, 2.11) |
| 25(OH)D | |||||
| ≥30 ng/mL | 2084 | 51 | 3.1 | Ref | Ref |
| 20 to 29 ng/mL | 2197 | 65 | 3.8 | 0.99 (0.67, 1.48) | 1.02 (0.68, 1.52) |
| <20 ng/mL | 2066 | 59 | 3.8 | 0.97 (0.60, 1.56) | 1.01 (0.61, 1.67) |
Model 3a: adjusted for age, sex, race/ethnicity, education, height, weight, smoking, physical activity level, diabetes, eGFR, urine ACR, systolic blood pressure, antihypertensive medications, calcium, phosphorus, FGF‐23, PTH/25(OH)D (alternative measure to the predictor). Model 3b: Model 3a +additionally adjusted for non‐fatal MI as a time‐varying covariate. ACR indicates albumin to creatinine ratio; eGFR, estimated glomerular filtration rate; HR, hazard ratio; MI, myocardial infarction; pys, person years.
These analyses were based on a complete case approach in which participants with missing covariate data were excluded (rather than using multiple imputation for missing covariates as was done for the primary analyses).