Table 1.
Physiological and Metabolic Parameters in Rats of the 4 Experimental Groups at 15 Weeks of Age
| Parameter | DS/Lean | DS/Obese | ||
|---|---|---|---|---|
| LS | NS | LS | NS | |
| Tibial length, mm | 39.0±0.2 | 39.1±0.2 | 35.9±0.3*† | 35.6±0.3*† |
| Heart rate, beats/min | 370±10 | 382±8 | 350±10† | 368±19 |
| Heart weight/tibial length, mg/mm | 29.8±0.6 | 30.5±0.8 | 35.1±1.2*† | 40.3±0.9*†‡ |
| LV weight/tibial length, mg/mm | 21.5±0.3 | 22.1±0.5 | 26.1±0.9*† | 31.4±0.6*†‡ |
| Visceral fat weight/tibial length, mg/mm | 92.7±6.2 | 98.3±6.8 | 426.4±12.6*† | 431.6±26.6*† |
| Subcutaneous fat weight/tibial length, mg/mm | 62.8±5.5 | 63.3±6.5 | 642.4±23.7*† | 612.3±63.9*† |
| Visceral adipocyte cross‐sectional area, μm2 | 3380±131 | 3467±190 | 10 544±136*† | 10 698±300*† |
| Glucose, mg/dL | 130.1±4.3 | 131.8±4.5 | 148.0±18.9 | 147.0±14.3 |
| Insulin, ng/mL | 0.55±0.17 | 0.38±0.08 | 4.43±1.14*† | 7.17±1.35*†‡ |
| HOMA‐IR | 4.37±1.26 | 3.05±0.64 | 36.08±8.01*† | 72.39±9.11*†‡ |
| Triglyceride, mg/dL | 68.4±5.8 | 65.5±6.6 | 3469.3±869.2*† | 1304.9±250.4*†‡ |
| Total cholesterol, mg/dL | 73.6±2.99 | 84.8±4.47 | 469.25±85.66*† | 297.38±22.73*†‡ |
| Free fatty acid, mEq/L | 0.89±0.09 | 0.95±0.13 | 1.40±0.11*† | 1.54±0.19*† |
| Adiponectin, ng/mL | 3965±128 | 3729±229 | 6257±229*† | 6030±332*† |
| TNF‐α, pg/mL | 4.21±1.40 | 5.21±0.90 | 6.33±1.00*† | 17.71±3.13*†‡ |
| IL‐6, pg/mL | 37.18±8.30 | 35.88±5.00 | 53.88±9.60*† | 122.01±14.54*†‡ |
Analytes were measured in serum unless indicated otherwise. Data are means±SEM (n=10, 10, 8, and 8 rats for DS/lean+LS, DS/lean+NS, DS/obese+LS, and DS/obese+NS groups, respectively). DS indicates Dahl salt; HOMA‐IR, homeostasis model assessment of insulin resistance; IL, interleukin; LS, low‐salt; LV, left ventricular; NS, normal‐salt; TNF, tumor necrosis factor.
*P<0.05 vs DS/lean+LS; †P<0.05 vs DS/lean+NS; ‡P<0.05 vs DS/obese+LS.