Table 2.
Cardiac Morphological and Functional Parameters of Rats in the 4 Experimental Groups at 15 Weeks of Age
| Parameter | DS/Lean | DS/Obese | ||
|---|---|---|---|---|
| LS | NS | LS | NS | |
| IVST, mm | 1.47±0.04 | 1.51±0.02 | 1.83±0.03*† | 2.08±0.03*†‡ |
| LVPWT, mm | 1.44±0.04 | 1.49±0.02 | 1.78±0.04*† | 2.06±0.03*†‡ |
| LVDd, mm | 8.09±0.19 | 8.36±0.19 | 8.60±0.32 | 8.51±0.22 |
| LVFS, % | 37.7±1.2 | 36.0±0.9 | 44.4±2.1*† | 45.7±1.9*† |
| RWT | 0.36±0.02 | 0.36±0.01 | 0.43±0.02*† | 0.49±0.02*†‡ |
| LV mass, mg | 834±30 | 920±40 | 1290±40*† | 1528±37*†‡ |
| E/A | 2.01±0.05 | 2.01±0.08 | 1.65±0.09*† | 1.34±0.06*†‡ |
| IRT, ms | 17.1±0.6 | 17.8±0.4 | 26.3±1.0*† | 31.5±0.9*†‡ |
| Tau, ms | 21.0±1.1 | 23.0±1.7 | 30.0±0.5*† | 39.8±2.5*†‡ |
| LVEDP, mm Hg | 2.62±0.36 | 2.50±0.20 | 5.07±0.48*† | 8.27±0.80*†‡ |
| LVEDP/LVDd, mm Hg/mm | 0.29±0.02 | 0.28±0.01 | 0.51±0.03*† | 0.85±0.01*†‡ |
Data are means±SEM (n=10, 10, 8, and 8 rats for DS/lean+LS, DS/lean+NS, DS/obese+LS, and DS/obese+NS groups, respectively). DS indicates Dahl salt; E/A, early to late ventricular; IRT, isovolumic relaxation time; IVST, interventricular septum; LS, low‐salt; LV, left ventricular; LVDd, LV end‐diastolic; LVEDP, LV end‐diastolic pressure; LVFS, LV fractional shortening; LVPWT, LV posterior wall thickness; NS, normal‐salt; RWT, relative wall thickness.
*P<0.05 vs DS/lean+LS; †P<0.05 vs DS/lean+NS; ‡P<0.05 vs DS/obese+LS.