. 2014 Dec 2;3(6):e001312. doi: 10.1161/JAHA.114.001312

Table 3.

Results of 2‐Way Factorial ANOVA in 4 Groups of Rats (DS/Lean+LS, DS/Lean+NS, DS/Obese+LS, and DS/Obese+NS)

Variable	P Value for the Interaction	Variable	P Value for the Interaction
Body weight, g	0.4098	ANP	<0.0001
Tibial length, mm	0.3453	BNP	0.0002
Food intake, g/day	0.5898	β‐MHC	0.0004
Water intake, mL/day	0.0905	Perivascular fibrosis	0.0474
SBP, mm Hg	0.004	Interstitial fibrosis, %	0.0006
Heart rate, beats/min	0.7671	Collagen type I	0.0398
Heart weight/tibial length, mg/mm	0.0122	Collagen type I/collagen type III	0.0285
LV weight/tibial length, mg/mm	0.0005	Fibronectin	0.0217
Visceral fat weight/tibial length, mg/mm	0.9890	DHE staining	0.0762
Subcutaneous fat weight/tibial length, mg/mm	0.6207	NADPH oxidase activity, RLU/mg protein	0.060
Visceral adipocyte cross‐sectional area, μm²	0.8717	p22^phox	0.8784
Glucose, mg/dL	0.8876	gp91^phox	0.4404
Insulin, ng/mL	0.0140	p47^phox	0.3057
HOMA‐IR	0.0006	p67^phox	0.5990
Triglyceride, mg/dL	0.0112	Rac1	0.0708
Total cholesterol, mg/dL	0.0268	CD68 positive cells (/mm²)	0.0597
Free fatty acid, mEq/L	0.7467	MCP‐1	0.5691
Adiponectin, ng/mL	0.9871	Osteopontin	0.0550
TNF‐α, pg/mL	0.0028	COX‐2	0.0241
IL‐6, pg/mL	0.0038	ACE	0.0905
IVST, mm	0.0033	AT_1A	0.8853
LVPWT, mm	0.0015	MR	0.2082
LVDd, mm	0.4473	Sgk1	0.1095
LVFS, mm	0.3097	MR protein	<0.0001
RWT	0.0333	CD68 positive cells in adipose tissue, %	0.0002
LV mass, mg	0.0284	MCP‐1 in adipose tissue	0.0105
E/A	0.0356	COX‐2 in adipose tissue	0.0205
IRT, ms	0.0023	TNF‐α in adipose tissue	0.0215
Tau, ms	0.0222	IL‐6 in adipose tissue	0.0455
LVEDP, mm Hg	0.0043	Akt phosphorylation	0.0359
LVEDP/LVDd, mm Hg/mm	0.0088	p70S6K phosphorylation	0.0080
Myocyte cross‐sectional area, μm²	<0.0001

ACE indicates angiotensin‐converting enzyme; ANP, atrial natriuretic peptide; AT_1A, angiotensin II type 1A receptor; BNP, brain natriuretic peptide; COX, cyclooxygenase; DS, Dahl salt; E/A, early to late ventricular; HOMA‐IR, homeostasis model assessment of insulin resistance; IL, interleukin; IRT, isovolumic relaxation time; IVST, interventricular septum; LS, low‐salt; LV, left ventricular; LVDd, LV end‐diastolic; LVEDP, LV end‐diastolic pressure; LVFS, LV fractional shortening; LVPWT, LV posterior wall thickness; MCP, monocyte chemoattractant protein; β‐MHC, β‐myosin heavy chain; MR, mineralocorticoid receptor; NADPH, nicotinamide adenine dinucleotide phosphate; NS, normal‐salt; RLU, relative light unit; RWT, relative wall thickness; SBP, systolic blood pressure; Sgk, serum‐ and glucocorticoid‐regulated kinase; TNF, tumor necrosis factor.