Table 3.

Risk of SCD, Adjusted by Demographic, Clinical and ECG Risk Factors (Model 3)

	All Participants (n=15 376)		CVD‐Free Participants (n=13 278)		Prevalent CVD (n=2098)
	HR (95%CI)	P Value	HR (95%CI)	P Value	HR (95%CI)	P (95%CI)
DTNPV1	2.37 (1.44 to 3.91)	0.001	3.51 (1.72 to 7.13)	0.001	2.05 (1.11 to 3.70)	0.022
Female	0.56 (0.41 to 0.77)	<0.0001	0.45 (0.32 to 0.68)	<0.0001	0.68 (0.41 to 1.11)	0.122
Age, y	1.006 (1.003 to 1.008)	<0.0001	1.07 (1.04 to 1.10)	<0.0001	1.04 (1.00 to 1.08)	0.057
CHD	0.30 (0.04 to 2.19)	0.234	—		0.82 (0.19 to 3.54)	0.417
MI	15.81 (2.17 to 114.96	0.006	—		6.22 (1.52 to 25.49)	0.011
HF	0.80 (0.53 to 1.23)	0.318	—		1.01 (0.63 to 1.60)	0.983
Stroke	1.80 (1.15 to 2.83)	0.010	—		2.22 (1.40 to 3.52)	0.001
BMI, kg/m2	1.00 (0.97 to 1.02)	0.848	0.99 (0.96 to 1.02)	0.647	1.01 (0.97 to 1.05)	0.568
Total cholesterol, mmol/L	1.21 (1.09 to 1.34)	<0.0001	1.18 (1.04 to 1.35)	0.009	1.27 (1.08 to 1.50)	0.003
HDL, mmol/L	0.57 (0.39 to 0.84	0.005	0.56 (0.36 to 0.89)	0.014	0.68 (0.35 to 1.31)	0.258
Triglycerides, mmol/L	0.98 (0.88 to 1.08)	0.679	0.97 (0.85 to 1.11)	0.663	0.96 (0.80 to 1.14)	0.637
Leisure activity index	0.87 (0.69 to 1.08)	0.209	0.75 (0.57 to 0.99)	0.046	—
Diabetes mellitus	2.24 (1.68 to 3.00)	<0.0001	2.82 (1.98 to 4.00)	<0.0001	1.56 (1.00 to 2.43)	0.048
Current smoking	2.00 (1.54 to 2.58)	<0.0001	2.13 (1.55 to 2.93)	<0.0001	1.68 (1.12 to 2.50)	0.011
Systolic blood pressure, mmHg	1.01 (1.01 to 1.02)	<0.0001	1.02 (1.01 to 1.02)	<0.0001	1.01 (1.01 to 1.02)	0.002
BP lowering drugs	1.35 (1.03 to 1.77)	0.029	1.74 (1.24 to 2.44)	0.001	0.95 (0.62 to 1.44)	0.794
QT‐prolonging drugs	1.05 (0.72 to 1.53)	0.787	1.01 (0.61 to 1.69)	0.958	1.03 (0.62 to 1.73)	0.903
Beta‐blockers	0.96 (0.67 to 1.53)	0.824	0.55 (0.30 to 1.01)	0.054	1.23 (0.78 to 1.94)	0.367
Cornell productsex, mm×ms	1.00 (1.00 to 1.00)	0.519	1.00 (1.00 to 1.00)	0.361	—
QRS duration, ms	1.00 (0.99 to 1.01)	0.411	0.98 (0.96 to 1.00)	0.098	1.02 (1.00 to 1.03)	0.004
Heart rate, bpm	1.01 (0.99 to 1.02)	0.367	1.00 (0.99 to 1.02)	0.621	1.02 (1.00 to 1.04)	0.027
QTc, ms	1.008 (1.003 to 1.014)	0.004	1.009 (1.001 to 1.017)	0.022	1.00 (0.99 to 1.01)	0.531
P duration, ms	1.00 (0.99 to 1.01)	0.462	0.99 (0.98 to 1.00)	0.131	1.01 (1.00 to 1.03)	0.046
P axis, deg	1.00 (0.99 to 1.00)	0.331	0.99 (0.99 to 1.00)	0.129	—
QRS‐T angle, deg	1.005 (1.002 to 1.009)	0.001	1.00 (1.00 to 1.01)	0.062	—
Itraatrial block third degree	1.20 (0.43 to 3.37)	0.727	1.38 (0.33 to 5.78)	0.660	—

CHD indicates coronary heart disease; DTNPV₁, deep terminal negativity of P wave in V₁; HF, heart failure; MI, myocardial infarction.