Table 5.
Risk of Non‐Fatal CHD, HF, Stroke, AF Events in CVD‐Healthy Participants With and Without DTNPV1
| Model | Non‐Fatal CHD (N=1422) | Heart Failure (N=910) | Stroke (N=505) | Atrial Fibrillation (N=699) | ||||
|---|---|---|---|---|---|---|---|---|
| HR (95%CI) | P Value | HR (95%CI) | P Value | HR (95%CI) | P Value | HR (95%CI) | P Value | |
| U | 2.61 (1.68 to 4.05) | <0.0001 | 4.57 (2.99 to 6.98) | <0.0001 | 3.97 (2.18 to 7.21) | <0.0001 | 6.35 (4.15 to 9.71) | <0.0001 |
| 1 | 2.27 (1.45 to 3.54) | <0.0001 | 2.88 (1.88 to 4.40) | <0.0001 | 2.43 (1.33 to 4.44) | 0.004 | 5.60 (3.64 to 8.61) | <0.0001 |
| 2 | 2.21 (1.41 to 3.46) | 0.001 | 2.29 (1.46 to 3.62) | <0.0001 | 2.26 (1.23 to 4.14) | 0.009 | 5.51 (3.58 to 8.50) | <0.0001 |
| 3 | 2.24 (1.43 to 3.53) | <0.0001 | 1.90 (1.19 to 3.04) | 0.007 | 1.88 (0.99 to 3.57) | 0.054 | 5.02 (3.23 to 7.80) | <0.0001 |
U, unadjusted; 1, Model 1 is adjusted for sex and age, stratified by race and study center. 2, Model 2 in addition adjusted by traditional risk factors: total cholesterol, triglycerides, high density lipoprotein, current smoking, diabetes mellitus, body mass index, leisure activity index, systolic blood pressure, use of blood‐lowering medications, QT‐prolonging drugs, beta‐blockers. 3, Model 3 in addition adjusted by ECG characteristics: heart rate, QRS duration, P duration, P axis, QTc, QRS‐T angle, sex‐specific Cornell product, third degree inter‐atrial conduction block. CHD indicates coronary heart disease; CVD, cardiovascular disease.