. 2014 Nov 10;3(6):e001398. doi: 10.1161/JAHA.114.001398

Table 5.

Sensitivity Analyses of the Top SNPs Associated With RHTN in INVEST‐GENES, After Removing INVEST‐GENES RHTN Cases That Were Not on a Diuretic

SNP	Chr	Position	Nearest Gene	Minor Allele	Race	MAF	OR (95% CI)	P Value	Meta‐Analysis OR (95% CI)	Meta‐Analysis P Value
rs12817819	12	88 563 457	ATP2B1	A	EA	0.126	1.55 (1.13 to 2.11)	0.0059	1.68 (1.35 to 2.01)	4.53E‐06
rs12817819	12	88 563 457	ATP2B1	A	Hispanic	0.113	1.90 (1.36 to 2.66)	1.76E‐04	1.68 (1.35 to 2.01)	4.53E‐06
rs324498	9	9 049 545	PTPRD	G	EA	0.170	1.53 (1.15 to 2.03)	0.0032	1.56 (1.30 to 1.82)	6.23E‐06
rs324498	9	9 049 545	PTPRD	G	Hispanic	0.273	1.58 (1.22 to 2.04)	5.60E‐04	1.56 (1.30 to 1.82)	6.23E‐06
rs2307023	12	21 804 552	KCNJ8	C	EA	0.408	1.41 (1.13 to 1.75)	0.0021	1.43 (1.23 to 1.64)	1.47E‐05
rs2307023	12	21 804 552	KCNJ8	C	Hispanic	0.368	1.46 (1.15 to 1.87)	0.0022	1.43 (1.23 to 1.64)	1.47E‐05
rs12314380	12	20 519 183	PDE3A	A	EA	0.021	4.53 (2.27 to 9.03)	1.79E‐05	1.45 (1.03 to 1.86)	3.19E‐05
rs12314380	12	20 519 183	PDE3A	A	Hispanic	0.110	1.34 (0.92 to 1.95)	0.1220	1.45 (1.03 to 1.86)	3.19E‐05
rs2299260	7	94 787 473	PON1	G	EA	0.179	1.42 (1.07 to 1.87)	0.0139	1.43 (1.18 to 1.67)	4.68E‐04
rs2299260	7	94 787 473	PON1	G	Hispanic	0.190	1.43 (1.08 to 1.89)	0.0128	1.43 (1.18 to 1.67)	4.68E‐04
rs10047560	12	20 496 483	PDE3A	A	EA	0.020	4.12 (2.04 to 8.34)	8.11E‐05	1.57 (1.13 to 2.01)	2.93E‐05
rs10047560	12	20 496 483	PDE3A	A	Hispanic	0.108	1.45 (1.00 to 2.12)	0.0530	1.57 (1.13 to 2.01)	2.93E‐05

SNP ID and chromosomal positions are based on NCBI build 36. Chr indicates chromosome; EA, European American; INVEST‐GENES, INternational VErapamil SR Trandolapril Study–GENEtic Substudy; MAF, minor allele frequency; OR, odds ratio; RHTN, resistant hypertension; SNP, single‐nucleotide polymorphism.