Table 5.
CMR Findings in Heterozygous Carriers Stratified by the Presence of Electrical Abnormalities
| Category | No Electrical Abnormality* (n=17) | Electrical Abnormality* (n=7) | P Value |
|---|---|---|---|
| RV EDV, mL | 165±42 | 156±22 | 0.591 |
| RV ESV, mL | 72±23 | 56±22 | 0.123 |
| RV EDV/BSA, mL/m2 | 82±18 | 86±15 | 0.654 |
| RV ESV/BSA, mL/m2 | 36±10 | 31±12 | 0.307 |
| RVEF, % | 57±7 | 64±11 | 0.067 |
| TFC major volume,* n (%) | 3/17 (18) | 1/7 (14) | 1.0 |
| TFC minor volume,* n (%) | 1/17 (6) | 1/7 (14) | 0.507 |
| TFC major RVEF,* n (%) | 0/17 (0) | 0/7 (0) | 1.0 |
| TFC minor RVEF,* n (%) | 0/17 (0) | 0/7 (0) | 1.0 |
| Any RV WMA, n (%) | 4/17 (24) | 0/7 (0) | 0.283 |
| RV akinesia, n (%) | 1/17 (6) | 0/7 (0) | 1.0 |
| RV dyskinesia, n (%) | 1/17 (6) | 0/7 (0) | 1.0 |
| RV dyssynchrony, n (%) | 2/17 (12) | 0/7 (0) | 1.0 |
| Any RV non‐WMA, n (%) | 7/17 (41) | 1/7 (14) | 0.352 |
| Microaneurysm, n (%) | 2/17 (12) | 1/7 (14) | 1.0 |
| Segmental dilation, n (%) | 1/17 (6) | 0/7 (0) | 1.0 |
| Accordion sign, n (%) | 2/17 (12) | 0/7 (0) | 1.0 |
| Fibrofatty replacement, n (%) | 0/17 (0) | 0/7 (0) | 1.0 |
| Trabecular hypertrophy, n (%) | 3/17 (18) | 1/7 (14) | 1.0 |
| LV EDV, mL | 148±29 | 146±24 | 0.844 |
| LV ESV, mL | 52±12 | 53±12 | 0.904 |
| LV EDV/BSA, mL/m2 | 74±13 | 80±16 | 0.32 |
| LVEF, % | 65±5 | 64±4 | 0.677 |
| Any LV finding, n (%) | 4/17 (24) | 2/7 (29) | 1.0 |
| LV wall thinning, n (%) | 3/17 (19) | 0/7 (0) | 0.526 |
| LV apical thinning, n (%) | 2/17 (12) | 2/7 (29) | 0.557 |
| LV hypokinesia/akinesia, n (%) | 0/17 (0) | 0/7 (0) | 1.0 |
| LV aneurysm, n (%) | 0/17 (0) | 1/7 (14) | 0.304 |
| CMR TFC major, n (%) | 2/17 (12) | 0/7 (0) | 1.0 |
| CMR TFC minor, n (%) | 0/17 (0) | 0/7 (0) | 1.0 |
Continuous variables expressed as mean±SD. RV indicates right ventricular; EDV, end‐diastolic volume; BSA, body surface area; ESV, end‐systolic volume; EF, ejection fraction; TFC, Task Force Criteria; WMA, wall motion abnormality; LV, left ventricular.
*
Electrical abnormality was defined as presence of any major or minor Task Force Criteria in depolarization, repolarization, or arrhythmia category.
*
Exceeds major cardiac magnetic resonance imaging (CMR) criteria cut‐off for volume.
*
Exceeds minor CMR criteria cut‐off for volume.
*
Exceeds major CMRI criteria cut‐off for RVEF.
*
Exceeds minor CMRI criteria cut‐off for RVEF.