Table 6.
Sex and Age Associations With RV Structural and Electrical Abnormalities in Heterozygotes
| Category | Male (n=14) | Female (n=14) | P Value | Age <50 y (n=18) | Age >50 y (n=10) | P Value |
|---|---|---|---|---|---|---|
| Electrical abnormalities,* n (%) | 3/14 (21) | 4/13 (31) | 0.678 | 3/17 (18) | 4/10 (40) | 0.365 |
| Any structural abnormality, n (%) | 6/12 (50) | 3/12 (25) | 0.4 | 4/15 (27) | 5/9 (56) | 0.212 |
| Regional WMA,* n (%) | 3/12 (25) | 1/12 (8) | 0.59 | 3/15 (20) | 1/9 (11) | 1.0 |
| Non‐WMA,* n (%) | 5/12 (42) | 3/12 (25) | 0.667 | 3/15 (20) | 5/9 (56) | 0.099 |
| RVEF, % | 57±11 | 61±6 | 0.219 | 56±5 | 63±13 | 0.103 |
RVEF indicates right ventricular ejection fraction.
*
Electrical abnormalities defined as presence of any major or minor Task Force Criteria in depolarization, repolarization, or arrhythmia categories.
*
WMA, wall motion abnormality (any of akinesis, dyskinesis, or dyssynchrony).
*
Presence of any of RV microaneurysms, segmental RV dilation, accordion sign, fibrofatty replacement, or trabecular hypertrophy.