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. 2015 Feb 24;9:47. doi: 10.3389/fncel.2015.00047

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Copyright © 2015 Masoli, Solinas and D'Angelo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ionic channel mutations and modulation in the model. The figure shows simulations of changes in firing pattern caused by gene mutations or pharmacological inhibition of PC ionic channels. Traces show model spontaneous firing (left) and complex bursting (right; 2 nA current injection). The plot shows the frequency-intensity relationships in the different cases. From top to bottom: Nav1.6 switch-off fully abolished firing; Cav2.1 switch-off prevented spontaneous firing and complex bursting; Kca1.1 switch-off prevented complex bursting; Kca2.2, Kv1.1, and Kv1.5 switch-off caused a slight increase in spontaneous and evoked firing; HCN1 switch-off did not alter spontaneous and evoked firing remarkably.