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. 2014 Aug 13;76(3):443–456. doi: 10.1002/ana.24230

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© 2014 The Authors Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Na_v1.1 levels are reduced in Scn1a^RX/+ mice, and this reduction is not prevented by tau ablation. Levels of Na_v1.1 and total sodium channels (pan Na_v) in the parietal cortex of 8-month-old mice were determined by Western blot analysis. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) levels were used as a loading control. (A) Representative Western blot. (B) Quantification of Western blot signals (n = 5–7 mice per genotype). The average Na_v1.1 to pan Na_v ratio in Scn1a^+/+/Tau^+/+ mice was arbitrarily defined as 1.0. ***p < 0.001 versus Scn1a^+/+/Tau^+/+ mice (Tukey–Kramer test). Values represent mean ± standard error of the mean.