Table 4.
Effects of dietary supplementation with FF, FF/AqSF-P, and FF/BY on body weight and food/drug intake in ND- and HCBD-fed mice
| Groups | Dose (%/w/w) | Body weight (g) at day 10 | Body weight – hepatic weight (g) at day 10 | Food intake (g/kg/day) | Drug intake (g/kg/day) |
|---|---|---|---|---|---|
| ND-fed mice | |||||
| ND | n/a | 28.45±0.47 | 26.72±0.41 | 173.32 | n/a |
| FF | 0.1 | 26.07±0.64** | 23.08±0.53** | 187.42 | 0.19 |
| FF/BY | 0.1/0.025 | 26.85±0.38* | 23.72±0.31** | 189.68 | 0.19/0.05 |
| FF/AqSF-P | 0.1/0.3 | 26.89±0.56* | 23.71±0.51** | 199.44 | 0.20/0.60 |
| 0.1/1 | 25.87±0.61** | 22.81±0.57** | 201.74 | 0.20/2.02 | |
| 0.1/3 | 26.20±0.72* | 23.20±0.61** | 182.33 | 0.18/5.47 | |
| 0.1/9 | 25.45±0.54** | 22.48±0.48** | 193.01 | 0.19/17.37 | |
| HCBD-fed mice | |||||
| ND | n/a | 28.46±0.67 | 26.72±0.60 | 195.36 | n/a |
| HCBD | n/a | 28.62±0.81 | 26.53±0.76 | 184.49 | n/a |
| FF | 0.03 | 30.30±0.72 | 26.79±0.67 | 183.83 | 0.06 |
| FF/BY | 0.03/0.025 | 29.78±0.53 | 26.29±0.42 | 178.31 | 0.05/0.03 |
| FF/AqSF-P | 0.03/3 | 29.24±0.70 | 26.00±0.59 | 180.92 | 0.06/5.47 |
| 0.03/9 | 29.32±0.52 | 25.80±0.42 | 193.72 | 0.06/17.39 | |
| HCBD-fed mice | |||||
| ND | n/a | 27.72±0.49 | 25.98±0.46 | 161.84 | n/a |
| HCBD | n/a | 28.02±0.24 | 25.95±0.23 | 170.91 | n/a |
| FF | 0.1 | 25.42±1.03# | 21.72±0.85## | 183.91 | 0.18 |
| FF/BY | 0.1/0.025 | 26.26±0.64# | 22.47±0.54## | 192.09 | 0.19/0.05 |
| FF/AqSF-P | 0.1/1 | 26.34±0.43## | 22.58±0.39## | 179.16 | 0.18/1.79 |
| 0.1/3 | 27.51±0.29 | 23.46±0.20## | 195.06 | 0.19/5.85 | |
| 0.1/9 | 24.50±0.59## | 21.04±0.52## | 181.28 | 0.18/16.32 | |
Notes: Mice were fed with ND or HCBD to establish a model of hypercholesterolemia. FF or the combination of FF and AqSF-P or BY at the indicated doses were supplemented with either ND or HCBD. The concentrations of AqFS-P were estimated on the basis of crude herbal material. Ten days after the dietary supplementation, body weight and food/drug intake were estimated. The dosages (g/kg/day) based on crude herbal material were determined with the amount of ingested diet (g/kg/day) and drug concentration in the diet. Values given are the means ± SEM, with n=10.
P<0.05
P<0.01 vs ND
P<0.05
P<0.01 vs HCBD. Statistically significant differences were determined using a one-way ANOVA, followed by Dunnett’s multiple-comparisons test.
Abbreviations: ND, normal diet; HCBD, high cholesterol/bile salt (0.5%/0.15%, w/w) diet; FF, fenofibrate; AqSF-P, aqueous extract of Schisandrae Fructus pulp; BY, bicyclol; SEM, standard error of mean; ANOVA, analysis of variance; w/w, weight/weight; vs, versus; n/a, not applicable.