Table 5.
HCBD (vs ND) | Dietary FF (vs ND or HCBD)
|
Dietary FF/AqSF-P (vs FF alone) | Dietary FF/BY (vs FF alone) | ||
---|---|---|---|---|---|
0.03% | 0.1% | ||||
ND-fed mice | |||||
Serum TC | n/a | n/a | ↓ | – | – |
Serum TG | n/a | n/a | ↓ | – | – |
Serum HDL | n/a | n/a | ↓ | – | ↓ |
Serum LDL | n/a | n/a | – | – | – |
Serum LDL/HDL | ↑ | – | – | ||
Serum ALT | n/a | n/a | ↑ | – | ↓ |
Hepatic TC | n/a | n/a | ↓ | ↓ | ↓ |
Hepatic TG | n/a | n/a | ↓ | ↓ | – |
Hepatic glucose | n/a | n/a | ↓ | ↓ | – |
Hepatic index | n/a | n/a | ↑ | – | – |
Fecal TC | n/a | n/a | – | – | – |
Fat index | n/a | n/a | ↓ | – | – |
Kidney index | n/a | n/a | ↑ | – | – |
Testis index | n/a | n/a | ↑ | – | – |
Body weight gain | n/a | n/a | ↓ | ↑ | ↑ |
HCBD-fed mice | |||||
Serum TC | ↑ | ↓ | ↓ | – | ↑ |
Serum TG | ↓ | – | – | – | – |
Serum HDL | – | ↓ | – | – | ↑ |
Serum LDL | ↑ | ↓ | ↓ | – | – |
Serum LDL/HDL | ↑ | ↓ | – | ↓ | – |
Serum ALT | ↑ | ↑ | ↑ | ↓ | ↓ |
Hepatic TC | ↑ | ↓ | ↓ | ↓ | ↓ |
Hepatic TG | ↑ | ↓ | ↓ | ↓ | ↓ |
Hepatic glucose | ↓ | ↓ | ↓ | ↓ | ↑ |
Hepatic index | ↑ | ↑ | ↑ | – | – |
Fecal TC | ↑ | – | ↑ | – | – |
Fat index | ↓ | ↓ | ↓ | – | – |
Kidney index | – | – | ↑ | ↑ | – |
Testis index | – | – | ↑ | – | – |
Body weight gain | – | – | ↓ | ↑ | – |
Notes: ↑, elevated or increased; ↓, inhibited or decreased; –, unaltered.
Abbreviations: ND, normal diet; HCBD, high cholesterol/bile salt (0.5%/0.15%, w/w) diet; FF, fenofibrate; AqSF-P, aqueous extract of Schisandrae Fructus pulp; BY, bicyclol; TC, total cholesterol; TG, triglyceride; HDL, high-density lipoprotein; LDL, low-density lipoprotein; ALT, alanine aminotransferase; vs, versus; n/a, not applicable.