Table 4.

Structure based approaches for prediction of PHIs.

Method	References
Comparative modeling of 3D structures	Davis et al., 2007
Sharing interacting partners of structurally similar human proteins to HIV proteins	Doolittle and Gomez, 2010
Structural similarity of Denv proteins to human proteins having known interactions	Doolittle and Gomez, 2011
3D structural interaction network of host-pathogen and within-host PPI networks	Franzosa and Xia, 2011
Assumes that structurally homologous proteins have probably interactors in common	De Chassey et al., 2013