Table 5.

Domain and motif based approaches for prediction of PHIs.

Method	References
PreDIN and PreSPI algorithms based on domain information	Kim et al., 2007
Estimating PPI probability using combining interaction probability of domains	Dyer et al., 2007
XooNET uses Structural Interactome MAP (PSIMAP), Protein	Kim et al., 2008
Experimental Interactome MAP (PEIMAP) and Domain-Domain interactions from iPfam
Based on ELMs on HIV-1 proteins interacting with human protein counter domains (CDs)	Evans et al., 2009
Predict and rank bacteria-human PPIs based on domain-domain interaction	Arnold et al., 2012
Build the virus-host interactomes by identifying domain interactions between virus and host PPIs followed by topological and functional analysis of the network	Zheng et al., 2014
The viral-human interaction network is modeled based on motif-domain interactions	Segura-Cabrera et al., 2013