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. 2015 Feb 19;3:e778. doi: 10.7717/peerj.778

Figure 1. LRRK2 heterologous interactions as reported in the merged dataset.

Figure 1

LRRK2 in the middle of the graph is linked to candidate partners (black dots) through 422 annotations as described in the merged dataset. Some partners have one connection only; others have multiple connections based on the number of annotations. Different colours represent different methods used to infer the interaction; note that since IntAct and BioGRID use different classifications for the interaction detection method, a simplified and harmonized version has been applied to this figure to help the reader. In particular: (i) Affinity Capture stands for—Affinity Capture-Western and Affinity Capture-MS (in BioGRID)—Anti Bait Coimmunoprecipitation, Anti Tag Coimmunoprecipitation, Coimmunoprecipitation, Pull Down and Affinity Chromatography Technology (in IntAct); (ii) Biochemical Activity stands for—Biochemical Activity (in BioGRID)—Protein Kinase Assay (in IntAct); (iii) Co-localization stands for—Co-localization (in BioGRID)—Confocal microscopy and Fluorescence Microscopy (in IntAct); (iv) Reconstituted Complex stands for—Fluorescence Polarization Spectroscopy and Surface Plasmon Resonance (in IntAct).