Table 1. LRRK2 interactors associated to the genetics of PD or IBD.
The approximate distance in base pair between the associated SNP and the protein coding sequence was calculated; the protein is indicated as candidate protein according to the original GWAs study.
| Protein | A | P | Methods | HTP | Familial PD |
GWA PD |
GWA IBD |
Associated SNP |
Distance (Kbp) |
Candidate |
|---|---|---|---|---|---|---|---|---|---|---|
| SNCA | 6 | 2 | IP, CM | − | X | X | rs356182 | ∼20 | Yes | |
| RAB7L1 | 5 | 1 | PA, IP, FM, CM | + | X | rs823118 | ∼14 | Yes | ||
| GAK | 5 | 2 | PA, IP, FM, CM | + | X | rs34311866 | ∼25 | Yes | ||
| MAPT | 7 | 2 | IP, BA | − | X | rs17649553 | 0 | Yes | ||
| CDC37 | 5 | 4 | MS, IP | + | X | rs11879191 | 0 | No | ||
| DVL1 | 4 | 1 | IP, CM, 2H | + | X | rs12103 | ∼23 | No | ||
| GNA12 | 1 | 1 | MS | + | X | rs798502 | 0 | Yes | ||
| CALM3 | 1 | 1 | MS | + | X | rs1126510 | ∼9.7 | Yes | ||
| GLTPD1 | 1 | 1 | PA | + | X | rs12103 | ∼13 | No | ||
| CEP72 | 1 | 1 | PA | + | X | rs11739663 | ∼18 | No | ||
| ARPC2 | 1 | 1 | MS | + | X | rs2382817 | ∼32 | Yes | ||
| RIPK2 | 1 | 1 | BA | − | X | rs7015630 | ∼73 | Yes | ||
| PSMG1 | 1 | 1 | PA | + | X | rs2836878 | ∼82 | No | ||
| DBN1 | 1 | 1 | MS | + | X | rs12654812 | ∼89 | No | ||
| RPAP3 | 1 | 1 | PA | + | X | rs11168249 | ∼108 | No | ||
| CD2BP2 | 1 | 1 | PA | + | X | rs11150589 | ∼116 | No | ||
| PLK1 | 1 | 1 | PA | + | X | rs7404095 | ∼163 | No | ||
| ACTR2 | 1 | 1 | MS | + | X | rs6740462 | ∼169 | No | ||
| STIP1 | 1 | 1 | PA | + | X | rs559928 | ∼178 | No | ||
| MYO1B | 1 | 1 | MS | + | X | rs1517352 | ∼179 | No | ||
| CLTC | 1 | 1 | MS | + | X | rs1292053 | ∼189 | No |
Notes.
- A
- number of annotations
- P
- number of publications
- HTP
- one of the detection methods is high throughput
Methods are as follows
- IP
- immunoprecipitation
- CM
- confocal microscopy
- FM
- fluorescent microscopy
- PA
- protein array
- BA
- biochemical activity
- MS
- affinity capture mass spectrometry
- 2H
- two hybrid