Table I.
Ganglioside concentrations in the brain of 64 day-old control and GalNAcT knockout mice. The results are expressed in nmoles ganglioside/g wet weight tissue. Values for individual gangliosides are expressed up to three significant digits, and the total is their arithmetic sums. The value 0 indicates below the level for reliable quantification. Note: GMx contains one mole of sialic acid per molecule. The corresponding mole numbers of sialic acid are two for GDx, three for GTx, and four for GQ, respectively. Refer to the legend for Fig. 1 regarding GT3 and O-acetylated GT3.
| Control | GalNAcT−/− | GalNAcT−/− saponified | |
|---|---|---|---|
| GM3 | 18 | 679 | 769 |
| GM2 | 29 | 0 | 0 |
| O-Ac-GD3 | 0 | 392 | 0 |
| GM1 | 327 | 0 | 0 |
| GD3 | 69 | 1140 | 1460 |
| GD1a | 579 | 0 | 0 |
| O-Ac-GT3 | 0 | 50 | 0 |
| GT3 | 0 | 20 | 92 |
| GD2 | 44 | 0 | 0 |
| GD1b | 176 | 0 | 0 |
| X (disialo?) | 103 | 0 | 0 |
| GT1b | 368 | 0 | 0 |
| GQ | 53 | 0 | 0 |
|
| |||
| TOTAL | 1766 | 2281 | 2321 |