Fig. 4.

Catalytic sites of F-ATPases and V-ATPases.

(A) Conserved residues in the catalytic subunits of F- and V-ATPases. The boxed areas denote the P-loop and the GERXXE sequence containing catalytic residues Lys155, Thr156 and Gln181 of F-ATPase. (B) The catalytic residues of E. coli F-ATPase and the corresponding residues of yeast V-ATPase are shown. Their positions are cited according to the bovine crystal structure.⁷⁾ Modified from reviews.^{1), 56)}